Protein-Lipid Interactions: From Membrane Domains to by Lukas K. Tamm

By Lukas K. Tamm

In 17 contributions via top learn teams, this primary finished instruction manual within the box covers the interactions among proteins and lipids that make the cloth of organic membranes from each attitude. It examines the suitable hermodynamic and structural matters from a simple technological know-how viewpoint, and is going directly to talk about biochemical and cellphone organic tactics. The e-book covers actual ideas in addition to mechanisms of membrane fusion and fission. also, chapters on bilayer constitution and protein-lipid interactions in addition to on how proteins form lipids and vice versa, membrane penetration by means of pollution, protein sorting, and allosteric rules of sign transduction throughout membranes make this a precious info resource for researchers in academia and undefined.

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Extra resources for Protein-Lipid Interactions: From Membrane Domains to Cellular Networks

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The best-understood sorting mechanism for transmembrane proteins employs recyclable protein coats, such as clathrin-, COPI- or COPII-coats [111, 112] (Fig. 1, left panel). In this case the cargo proteins contain specific sorting signals in their cytoplasmic domains, which are bound by adaptor molecules, to which the coat proteins are recruited. Oligomerization of the coats leads to bending of the membrane domain into a vesicle, which is pinched off by the action of the GTPase dynamin and released into the cytosol.

Adding the curvature energy to the energy of membrane tension, the total energy of a patch of membrane of area S, with a curvature C is 27 28 2 The Forces that Shape Caveolae F = gS + 1 kS(C – C0)2 2 (2) A Typical value for the bending rigidity of biomembranes [10] is k = 20 kBT. It is convenient to measure energies in units of the thermal energy scale which, at room temperature is, kBT = 4 V 10–21 J. 4 kBT. In this chapter, we will be mostly concerned by the flask-shaped membrane deformations mimicking the caveolae (Fig.

W. L. Vaz, and T. E. Thompson, Lateral diffusion and percolation in two-phase, two-component lipid bilayers. Topology of the solid-phase domains in-plane and across the lipid bilayer. Biochemistry 1992; 31(31): 7198–7210. Coelho, F. , W. L. Vaz, and E. Melo, Phase topology and percolation in twocomponent lipid bilayers: a Monte Carlo approach. Biophys. J. 1997; 72(4): 1501–1511. References 80 Abreu, M. , M. J. Moreno, and W. L. Vaz, 81 82 83 84 85 86 87 88 89 90 91 Kinetics and thermodynamics of association of a phospholipid derivative with lipid bilayers in liquid-disordered and liquid-ordered phases.

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