By K. Heremans (auth.), Professor Dr. Roland Winter (eds.)
At current, there's a transforming into curiosity in excessive strain bioscience and
biotechnology. The actions are approximately both disbursed between
fundamental learn and functions. With unique paintings on
biochemistry, biophysics, marine and terrestrial micobiology,
pharmacology, foodstuff technological know-how and different functions, this publication covers the
whole variety of present excessive strain bioscience. Advances in High
Pressure Bioscience and Biotechnology should be welcomed via all academic
and business researchers who're operating during this field.
The following themes are lined:
High strain results on proteins and macromolecules
High strain results on polyelectrolytes, DNA, RNA
High strain results on lipids and biomembranes
High strain and enzymatic reactions
High strain microbiology
High strain nutrients technological know-how and nutrients technology
High strain functions in bioscience, pharmacy, and medicine
High strain ideas
Read or Download Advances in High Pressure Bioscience and Biotechnology II: Proceedings of the 2nd International Conference on High Pressure Bioscience and Biotechnology, Dortmund, September 16–19, 2002 PDF
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Extra info for Advances in High Pressure Bioscience and Biotechnology II: Proceedings of the 2nd International Conference on High Pressure Bioscience and Biotechnology, Dortmund, September 16–19, 2002
De Abstract. Oligomeric proteins generally tend to dissociate under pressure, while aggregation is often observed in the pressure-denatured state. We report on a pressure-induced association of native myoglobin in the lowpressure regime. Depending on solvent conditions, the monomer becomes unstable above a critical pressure. The association process involves an initial lag phase due to seed formation, an intermediate reversible oligomeric state and a final structurally altered precipitate. Using static and dynamic light scattering, we discuss the kinetics of association, the effect of pH, temperature and buffer conditions on the stability limit.
Schulte Materials and Methods Horse skeletal muscle met-myoglobin was obtained from Sigma and dissolved in 100 mM phosphate-buffer using a protein-concentration of 50 M (1 mg/ml) for the light scattering experiments and 8 M for the spectroscopic studies. The sample was centrifuged at 20000 g and used without further purification. Controls were performed using material purified by ceramic hydroxyl apatit. The association process under pressure was monitored by static and dynamic light scattering (ALV-Laser GmbH, Langen) in a thermostated SITEC high-pressure cell.
111, 5568 (1999). V. Madison, K. D. Kopple, J. Am. Chem. Soc. 102, 4855 (1980). T. Imai, M. Kinoshita, F. Hirata, J. Chem. Phys. 112, 9469 (2000). M. Kinoshita, T. Imai, A. Kovalenko, F. Hirata, Chem. Phys. Lett. 348, 337 (2001). T. Imai, Y. Harano, A. Kovalenko, F. Hirata, Biopolymers. 59, 512 (2001). High Pressure as Tool to Study Structural Properties of Thiolate Heme Proteins C. Jung1, B. C. de Abstract. A membrane driven high-pressure cell with sapphire anvils is used to measure the CO ligand stretch mode of various substrate complexes of cytochrome P450cam.