Adrenomedullin in Cardiovascular Disease by Kazuo Kitamura, Kenji Kangawa, Tanenao Eto (auth.), Toshio

By Kazuo Kitamura, Kenji Kangawa, Tanenao Eto (auth.), Toshio Nishikimi MD, PhD (eds.)

Adrenomedullin used to be came upon in 1993 in an extract of human pheochromocytoma whereas tracking cAMP degrees in rat platelets. Adrenomedullin has attracted huge curiosity between cardiologists because of its influence at the cardiovascular approach which incorporates a lessen in blood strain in vivo; an effect on vascular soft muscle cells; raises cAMP degrees; in a roundabout way reduces blood strain and has a task within the pathogenesis of arteriosclerosis.

Adrenomedullin in heart problems is an updated assessment of the main correct features of adrenomedullin. It includes a huge variety of fields together with biochemistry, molecular biology, body structure, pharmacology, pathophysiology of heart problems and medical purposes of adrenomedullin to cardiovascular disease.

Toshio Nishikimi, MD, PhD, is an affiliate Professor within the division of high blood pressure and Cardiorenal drugs, Dokkyo college tuition of drugs, Tochigi, Japan.

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Nishimatsu H, Suzuki E, Nagata D, Moriyama N, Satonaka H, Walsh K, Sata M, Kangawa K, Matsuo H, Goto A, Kitamura T, and Hirata Y (2001) Adrenomedullin induces endothelium-dependent vasorelaxation via the phosphatidylinositol 3-kinase/Akt-dependent pathway in rat aorta. Circ Res 89:63-70. Njuki F, Nicholl CG, Howard A, Mak JC, Barnes PJ, Girgis SI, and Legon S. (1993) A new calcitonin-receptor-like sequence in rat pulmonary blood vessels. Clin Sci (Lond) 85:385-388. Nuki C, Kawasaki H, Kitamura K, Takenaga M, Kangawa K, Eto T, and Wada A.

1998). , 1996). Considering that NF-IL6 has been shown to be induced by stimulation with IL-1, TNF-a and IL-6 itself, NF-IL6 may partly mediate these increases in AM induced by cytokines. In the acute-phase reaction against inflammation or tissue injury, NF-IL6 is assumed to play an important role as a transcription factor. It is speculated that AM, induced by NF-DL6, dilates regional blood vessels and facilitates the delivery of blood and leukocytes to the inflamed tissue. ,2002). , 2000), and Cormier-Regard et al.

1996) Identification of a protein that confers calcitonin gene-related peptide responsiveness to oocytes by using a cystic fibrosis transmembrane conductance regulator assay. ProcNatl Acad SciU S A93:3455-3460. Martinez A, Elsasser TH, Muro-Cacho C, Moody TW, Miller MJ, Macri CJ, and Cuttitta F. (1997) Expression of adrenomedullin and its receptor in normal and malignant human skin: a potential pluripotent role in the integument Endocrinology 138:5597-5604. McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, and Foord SM.

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